Keanu Reeves goes down the rabbit hole in first trailer for 'The Matrix Resurrections'

"After all these years, to be going back to where it started ... Back to the Matrix"

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After a long wait, Matrix fans got their first look Thursday at Keanu Reeves’ return as Neo in the trailer for The Matrix Resurrections.

The trailer to the long-awaited fourquel, which hits theatres on Dec. 22 and comes 18 years after The Matrix Revolutions, opens in a therapist’s office where Neo, going by the name Thomas Anderson, is complaining about “dreams that weren’t just dreams” and wondering if he’s “crazy.”

“We don’t use that word in here,” the therapist, played by Neil Patrick Harris, replies.

The storyline of the original trilogy followed Neo and a group of heroes as they battled against futuristic machines that have imprisoned humankind in a lifelike virtual reality simulation.

Set to Jefferson Airplane’s White Rabbit, the first look at The Matrix Resurrections finds Thomas gulping down blue pills that help keep his reality in check and muffle events from the early films. When he meets Trinity (Carrie-Anne Moss), they initially don’t remember one another. “Have we met?” she asks.

But eventually, it’s “time to fly” when Yahya Abdul-Mateen II, possibly as a young Morpheus, offers Thomas a red pill.

Keanu Reeves as Neo/Thomas Anderson in The Matrix Resurrections. Warner Bros.

Once he’s been enlightened, Jessica Henwick (Iron Fist), sporting a rabbit tattoo, tells him if he wants the truth “you’re going to have to follow me” — a callback to the 1999 original.

Next we see Abdul-Mateen II and Reeves sparring and plenty of high-flying action, including Neo and Trinity leaping off a rooftop, but the true plot — and whether this is a sequel or a start of something new — remains a mystery.

“After all these years, to be going back to where it started,” a new character played by Jonathan Groff teases. “Back to the Matrix.”

Directed by Lana Wachowski, The Matrix Resurrections also features Priyanka Chopra Jonas and Christina Ricci, along with returning series stars Jada Pinkett Smith (Niobe), Lambert Wilson (the Merovingian) and Daniel Bernhardt (Agent Johnson).

“Lana Wachowski wrote a beautiful script and a wonderful story that resonated with me,” Reeves, 57, told Empire magazine in its Heroes issue last year. “That’s the only reason to do it. To work with her again is just amazing.”

He added, “The story has, I think, some meaningful things to say, and that we can take some nourishment from.”

In other words, “Whoa, dude … we’re in for something great.”

The Matrix Resurrections opens in theatres Dec. 22.